It was founded in 12th century. Some years later the Plyos fortress (ru) was founded. It was destroyed in 1238 by Mongols.
A border post of the Grand Duchy of Moscow was founded in 1410 by Vasily I. It was granted town status in 1925.
Within the framework of administrative divisions, Plyos is subordinated to Privolzhsky District. Prior to the adoption of the Law #145-OZ On the Administrative-Territorial Division of Ivanovo Oblast in December 2010, it used to be incorporated separately as an administrative unit with the status equal to that of the districts.
As a municipal division, the town of Plyos, together with twenty-three rural localities in Privolzhsky District, is incorporated within Privolzhsky Municipal District as Plyosskoye Urban Settlement.