Located by the island's capital, Nuuk, it is the longest fjord on the Labrador Sea coast of Greenland, and one of the longest in the inhabited part of the country.
The fjord head is located deep inland, with the fjord beginning as an icefjord at 64°19′50″N 49°36′10″W / 64.33056°N 49.60278°W / 64.33056; -49.60278, with two glaciers draining the Greenland ice sheet (Greenlandic: Sermersuaq) flowing into the fjord.
Initially, the fjord flows to the northwest, to then turn southwest at 64°43′N 50°37′W / 64.717°N 50.617°W / 64.717; -50.617, splitting into three arms in its lower run, with three large, mountainous islands in between the arms: Sermitsiaq Island with the Sermitsiaq mountain visible from most of Nuuk, Qeqertarsuaq Island, and Qoornuup Qeqertarsua Island.
The fjord widens into a bay dotted with skerries near its mouth, opening into Labrador Sea at approximately 64°03′N 51°58′W / 64.050°N 51.967°W / 64.050; -51.967, near the former Kangeq settlement.
Nuuk, the capital of Greenland, is located near the mouth of the fjord, on a mountainous peninsula bounding the fjord from the southeast. Kapisillit is located 75 km (47 mi) northeast of Nuuk, near the head of Kapisillit Kangerluaq, one of the tributary fjords of Nuup Kangerlua.
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