The main transport and commercial centre in the region is Nicoya, one of the oldest settlements in Costa Rica. Ferries run between the town of Puntarenas on the mainland and the Nicoya Peninsula. There is an international airport in Liberia and small domestic airstrips in Nosara, Carrillo and Tambor. The region was also featured in the book Blue Zones, by Dan Buettner, which focused on the longevity found among Nicoya's residents.
Other notable settlements and places of interest in the area include (going roughly from north to south): Tamarindo, Santa Cruz, Nosara, Sámara, Naranjo, Paquera, Curu, Tambor, Montezuma, Santa Teresa, Mal Pais.
There are a number of nature reserves and wildlife refuges such as Cabo Blanco, Camaronal, Cueva Murciélago, Curú, La Ceiba, Romelia and the Diria National Park, as well as the projects on the islands of the adjacent Gulf of Nicoya.
The Nicoya Peninsula is considered by Quest Network one of the Blue Zones in the world, where people commonly live active lives past the age of 100 years.