Cadillac is directly across the Garonne river from Sauternes, and is known for producing sweet dessert wines under the Cadillac AOC designation.
Cadillac was founded in 1280 to serve as a river port for the castle of Benauges by the lord of the castle, Jean I de Grailly.
Cadillac is the home of the imposing Château des Ducs d'Épernon.
The name of the commune was adopted by Antoine Laumet de La Mothe, sieur de Cadillac, the founder of Detroit and Governor of Louisiana, on his arrival to what is now the United States. The Cadillac division of General Motors, and Cadillac, Michigan are named after him.